Biology: The Science of Life

Course No. 1500
Professor Stephen Nowicki, Ph.D.
Duke University
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Course No. 1500
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  • You should buy audio if you would enjoy the convenience of experiencing this course while driving, exercising, etc. While the video does contain visual elements, the professor presents the material in an engaging and clear manner, so the visuals are not necessary to understand the concepts. Additionally, the audio audience may refer to the accompanying course guidebook for names, works, and examples that are cited throughout the course.
  • You should buy video if you prefer learning visually and wish to take advantage of the visual elements featured in this course. The video version is well illustrated and features more than 450 graphs, photographs, charts, experiments, diagrams, and portraits. There are many photographs and illustrations of animals and organisms of all sizes, diagrams of Punnett Squares (which show the possibilities of genetic inheritance), graphics that depict the evolutionary similarities in mammalian bone structures, and portraits of famous biologists including Gregor Mendel and Thomas Hunt Morgan. There are on-screen spellings and definitions to help reinforce material for visual learners.
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What Will You Learn?

  • Explore how DNA stores, transmits, and modifies genetic information.
  • Discover how single cells work together to form complex multicellular organisms.
  • Examine how living systems obtain the energy and other materials needed to maintain their highly ordered state.
  • Make better sense of biology with help from hundreds of photographs, diagrams, animations, and on-screen text.

Course Overview

One of the greatest scientific feats of our era is the astonishing progress made in understanding the intricate machinery of life. We are living in the most productive phase so far in this quest, as researchers delve ever deeper into the workings of living systems, turning their discoveries into new medical treatments, improved methods of growing food, and innovative new products.

"The 21st century will be the century of biological science, just as the 20th century was the century of physical science," predicts Professor Stephen Nowicki, an award-winning teacher at Duke University who has specially adapted his acclaimed introductory biology course for The Teaching Company to bring you up to date on one of the most important fields of knowledge of our time.

This intensive, 72-lecture course will give you the background and guidance to explore in depth the fundamental principles of how living things work—principles such as evolution by natural selection, the cellular structure of organisms, the DNA theory of inheritance, and other key ideas that will help you appreciate the marvelous diversity and complexity of life.

Explore Living Systems at All Levels

Make no mistake: This is a challenging course. But the rewards are tremendous. You will explore living systems at all levels, from biological molecules to global ecosystems. Along the way, you will gain insight into some of the most pressing questions facing society:

  • What does it mean to say that the human genome has been sequenced, and why should we sequence the genomes of other species?
  • How is an organism genetically modified or cloned, and what are the benefits—or potential costs—of doing so?
  • What are stem cells, and how might they contribute to health and welfare?
  • Why is HIV/AIDS so difficult to treat?
  • What will happen if vast tracts of tropical rainforest are cut down, and why does it matter that the temperature of the Earth is rising?

In addition, you will discover the mechanisms behind such intriguing phenomena as why children resemble their parents, what causes plants to bend toward light, how memories are stored, why some birds have very long tails, and how life itself began on Earth.

Above all, you will learn how to think about biology, so that in your day-to-day life you will understand the significance and complexities of news stories, medical issues, and public debates, not to mention what is going on in your own garden and in nature all around you.

The Unifying Themes of Biology

Professor Nowicki presents the subject in a conceptual format, emphasizing the importance of broad principles. Facts and details are offered in abundance, but in the context of developing a framework that listeners can absorb.

The course is organized around three unifying themes:

  • Starting with "Information and Evolution" (Lectures 1-24), you investigate how information about the structure and organization of living things is found in the DNA molecule, how this information is transmitted and modified, and the implications of these processes for understanding life. One important conclusion of this discussion is that species inevitably change over time; that is, that life evolves.
  • In "Development and Homeostasis" (Lectures 25-48), you consider two related issues for understanding the workings of complex organisms: how single cells (fertilized eggs) proliferate and transform into complex, multicellular organisms, and how parts of complex organisms remain coordinated and maintain their integrity in the face of different challenges.
  • In "Energy and Resources" (Lectures 49-72), you learn how living systems obtain the energy and other materials needed to maintain their highly ordered state and the implications of these processes for understanding the organization of biology at all levels of scale. Ultimately this investigation leads into the discipline of ecology and to considerations of energy and resource limitations for the entire planet.

The Great Experiments of Biology

One of the distinctive features of this course is that you learn much of the material through the great experiments that revealed new and unexpected aspects of the living world to science, including:

  • Gregor Mendel discovered the fundamental principles of inheritance through his work on trait transmission in garden peas in the mid-1800s
  • Thomas Hunt Morgan introduced the fruit fly as a model system for modern genetics in the early 20th century. Morgan's work and that of his many students demonstrated that genes occur on chromosomes.
  • Konrad Lorenz's mid-20th-century work on releasers and fixed action patterns in the behavior of greylag geese and other animals helped establish the modern study of animal behavior.
  • Arthur Kornberg's discovery of DNA polymerase in 1958 helped spark today's revolution in biotechnology and genetic engineering.

In your systematic study of biology under Professor Nowicki's guidance, you will encounter a wealth of interesting information and observations, such as:

  • Some cells in a developing organism are preprogrammed to die, a process that is important, for example, in creating the spaces between our fingers and toes.
  • The accumulation of oxygen in Earth's atmosphere following the evolution of photosynthetic bacteria was a disaster of global proportions for most of the organisms that lived before oxygen appeared on the planet.
  • The ability of cells to recognize self from non-self is widespread in animals, even among creatures as simple as sponges. If you take two sponges of the same species and dissociate their cells, then mix those cells, the cells will reassociate with the individual they came from.
  • Some species of moths and butterflies develop into different looking caterpillars or adults depending on the time of year that they happen to be born. It is the available food source that turns the caterpillar into one form or another.

The diversity of life is indeed remarkable—and so will be your experience with this course. You may not understand everything the first or even the second time you hear it, but "the point isn't to remember the details," says Professor Nowicki. "The point is to understand how the details are processed, how they're analyzed, how biologists come up with these ideas, and how to think about the new information you might encounter in the future.

"My goal in teaching is to have somebody able to open up a newspaper and say, 'I understand why this is an important discovery in biology.'"

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72 lectures
 |  Average 30 minutes each
  • 1
    The Scope of "Life"
    The first lecture gives an overview of biology, raising key questions about the nature of life and the origin of living things, and concludes with an outline of the structure of the course. x
  • 2
    More on the Origin of Life
    This lecture outlines the challenges of evolution for living entities such as we recognize today, and reviews experimental data suggesting how these challenges might have been met. The process of reproduction identifies the concept of information in biology, and introduces the connecting theme for the first third of the course. x
  • 3
    The Organism and the Cell
    Professor Nowicki outlines the hierarchical nature of biological systems and introduces two fundamental levels of the hierarchy: the organism and the cell. x
  • 4
    Proteins—How Things Get Done in the Cell
    This lecture describes the four major classes of biomolecules—lipids, carbohydrates, nucleic acids, and proteins—and discusses the role of proteins in the life of the cell. x
  • 5
    Which Molecule Holds the Code?
    Key experiments in the first half of the 20th century led to the conclusion that DNA is the information-carrying molecule. x
  • 6
    The Double Helix
    Experiments by Rosalind Franklin, Maurice Wilkins, and others led to the discovery by James Watson and Francis Crick of the double helix structure of DNA, suggesting a mechanism by which the information in DNA can be replicated. x
  • 7
    The Nuts and Bolts of Replicating DNA
    After describing how the theory of DNA replication was confirmed, Professor Nowicki summarizes the process, which has been the key to understanding and manipulating biological systems. x
  • 8
    The Central Dogma
    We are introduced to the "central dogma" of molecular biology: Genetic information flows in one direction only—from DNA to RNA to proteins, not in reverse. x
  • 9
    The Genetic Code
    How is protein structure coded in DNA? This lecture describes the experiments that cracked the code and examines the code's defining properties. x
  • 10
    From DNA to RNA
    Step one in the journey of genetic information from DNA to proteins is the process of transcription, by which messenger RNA is made from a DNA template. x
  • 11
    From RNA to Protein
    Completing the description of how genetic information finds its way to functional proteins, this lecture covers the process of translation, which is the synthesis of proteins based on an RNA template. x
  • 12
    When Mistakes Happen
    We learn the causes for errors that creep into DNA during copying and the mechanisms that have evolved to detect and repair those errors. x
  • 13
    Dividing DNA Between Dividing Cells
    Moving from the molecular level to the level of cells and organisms, this lecture addresses the question: When a new being is produced, how does it acquire DNA from its parents? x
  • 14
    Mendel and His Pea Plants
    The first of two lectures on Gregor Mendel's 19th-century experiments on the genetics of pea plants shows how this work anticipated the modern understanding of genes, chromosomes, and the formation of gametes during meiosis. x
  • 15
    How Sex Leads to Variation
    This lecture continues the discussion of Mendel's contributions to genetics, turning to subsequent experiments in which he looked at the transmission of more than one trait. x
  • 16
    Genes and Chromosomes
    We explore the understanding of the cellular and molecular basis of genetics that emerged after Mendel at the turn of the 20th century. x
  • 17
    Charles Darwin and "The Origin of Species"
    At almost the same time that Mendel was working on his laws of inheritance, Charles Darwin was completing his theory of natural selection, which sought to explain the change of species over time. x
  • 18
    Natural Selection in Action
    This lecture presents several examples that demonstrate natural selection in action, including data from both field studies and laboratory experiments. x
  • 19
    Reconciling Darwin and Mendel
    The apparent conflict between Mendel and Darwin was resolved through the "modern synthesis," which models gene frequency changes in populations. x
  • 20
    Mechanisms of Evolutionary Change
    Natural selection is not the only cause of evolution. Other factors can produce changes in the gene pool of a population, the most notable being genetic drift. x
  • 21
    What Are Species and How Do New Ones Arise?
    Professor Nowicki discusses problems with the biological species concept, introduces alternate definitions, and describes the process of allopatric speciation. x
  • 22
    More on the Origin of New Species
    Continuing the discussion of how new species arise, this lecture looks at sympatric speciation, which occurs in the absence of physical separation of populations. x
  • 23
    Reconstructing Evolution
    How do biologists organize the enormous diversity of living things? We learn about phylogenetic systematics as an approach for reconstructing evolutionary history. x
  • 24
    The History of Life, Revisited
    This lecture takes a final look at the concept of information and evolution in biology by returning to the question of how an original, primordial life form might have given rise to the complex biodiversity observed today. x
  • 25
    From Cells to Organisms
    This lecture recaps material presented to this point and introduces the second major section of the course, "Development and Homeostasis," by looking at the mystery of complex, multicellular, self-regulating organisms. x
  • 26
    Control of Gene Expression I
    What makes cells different? We look at the mid 20th-century experiments of Jacques Monod and François Jacob in search of the mechanisms of gene regulation. x
  • 27
    Control of Gene Expression II
    We continue our investigation of how the proteins in a cell are determined by mechanisms that turn on and off the expression of specific genes. x
  • 28
    Getting Proteins to the Right Place
    Producing the right proteins at the right time is only the first step. This lecture explains how proteins find themselves in the right places inside or outside a cell. x
  • 29
    Genetic Engineering and Biotechnology
    The mechanisms cells use to replicate and transcribe DNA have shown researchers how to modify genes, transfer genetic material, and sequence genes. x
  • 30
    How Cells Talk—Signals and Receptors
    This lecture is the first of two that explore how molecular messages control cell function, focusing on how signals outside the cell get their message to the inside of the cell. x
  • 31
    How Cells Talk—Ways That Cells Respond
    Continuing the discussion of extracellular signals and cell function, this lecture focuses on the molecular mechanisms by which signals can change the way cells work. x
  • 32
    From One Cell to Many in an Organism
    How does a single cell develop into a fully formed organism? This lecture outlines the major questions surrounding development. x
  • 33
    Patterns of Early Development
    Professor Nowicki describes the four earliest stages of animal development—fertilization, cleavage, gastrulation, and organogenesis—outlining the processes involved in each. x
  • 34
    Determination and Differentiation
    Developmental processes cause cells to differentiate into many different types of cells. One such mechanism is cytoplasmic segregation. x
  • 35
    Induction and Pattern Formation
    The second major mechanism involved in differentiation is induction, in which cells stimulate each other to develop in different ways. x
  • 36
    Genes and Development
    This lecture examines the development of the Drosophila melanogaster (fruit fly) as an example of the influence of specific genes on pattern formation. x
  • 37
    Homeostasis
    Homeostasis refers to an organism's ability to maintain a constant internal environment. We explore the nature of this mechanism and look at examples such as the regulation of body temperature. x
  • 38
    Hormones in Animals
    Homeostasis requires the different parts of a complex organism to communicate with each other. This lecture focuses on the endocrine system, which uses chemical signals called hormones to transmit physiological information. x
  • 39
    What is Special about Neurons?
    This lecture begins a discussion of the nervous system by examining neurons and the properties that enable them to transmit information over long distances at high speeds. x
  • 40
    Action Potentials and Synapses
    We review the initiation of action potentials and discuss how the anatomy of the neuron allows action potentials to propagate along the axon. x
  • 41
    Synaptic Integration and Memory
    In addition to transmitting information, the nervous system must also be able to process it. This lecture covers how inputs to a typical neuron are processed and stored. x
  • 42
    Sensory Function
    This lecture looks at the basic principles underlying sensory function—the mechanism by which animals obtain information from their environment. x
  • 43
    How Muscles Work
    Turning to the output side of cell function, Professor Nowicki examines muscles, describing the molecular basis for how muscle cells change their shape and exert force in doing so. x
  • 44
    The Innate Immune System
    How do animals defend themselves from injury or infection? We see how the nonspecific, or innate, immune response provides a general defense. x
  • 45
    The Acquired Immune System
    What happens if an infection can't be handled by nonspecific defenses? This is where the more specifically targeted and more efficient mechanisms associated with acquired immunity come into play. x
  • 46
    Form and Function in Plants I
    This lecture begins an examination of plant structure, development, and physiology, illustrating similarities and differences with analogous processes in animals. x
  • 47
    Form and Function in Plants II
    We continue our study of plant form and function by looking at how homeostasis is maintained in plants and by examining the ways plants respond to the external environment. x
  • 48
    Behavior as an Adaptive Trait
    This lecture discusses the adaptive significance of the ways organisms respond to stimuli. Why are some behaviors inflexible and others not? x
  • 49
    Energy and Resources in Living Systems
    Starting with a review of previous material, Professor Nowicki sets the stage for the third major theme of the course, "Energy and Resources," which moves from the level of molecules to global ecosystems. x
  • 50
    How Energy is Harnessed by Cells
    We look at the process by which cells obtain energy from a molecule called adenosine triphosphate (ATP). x
  • 51
    Enzymes—Making Chemistry Work in Cells
    Activation energy is the initial "push" required for a chemical reaction to proceed. This lecture examines the role and function of enzymes in facilitating chemical reactions in cells, which they do by effectively lowering this activation energy. x
  • 52
    Cellular Currencies of Energy
    We explore the chemical nature of ATP that allows it to serve as an energy "currency" for cells, and learn how energy is stored in glucose and other organic molecules, which allow them to act as a cellular "fuel" for making more ATP. x
  • 53
    Making ATP—Glycolysis
    This lecture introduces the three energy-producing metabolic processes in the cell—glycolysis, the Krebs cycle, and the electron transport chain—and looks in depth at glycolysis. x
  • 54
    Making ATP—Cellular Respiration
    Glycolysis extracts relatively little of the energy available in glucose. The complete harvest of this energy involves several additional processes, including the Krebs cycle and the electron transport chain. x
  • 55
    Making ATP—The Chemiosmotic Theory
    The electron transport chain is the process that ultimately uses the energy extracted from the breakdown of organic molecules such as glucose to drive the production of ATP, but how this worked was a mystery for decades. This lecture outlines the radical theory that finally solved this puzzle. x
  • 56
    Capturing Energy from Sunlight
    Living things require fuel to generate ATP. Some organisms generate fuel by converting the energy of sunlight into high-energy organic compounds through the process of photosynthesis. x
  • 57
    The Reactions of Photosynthesis
    Where does the added mass come from when a plant grows? The answer leads us to consider the reactions of photosynthesis and the Calvin cycle. x
  • 58
    Resources and Life Histories
    Many organisms have the capacity for the kind of explosive population growth associated with bacteria. Asking why such unchecked growth is rare provides a transition to considering energy and resources at higher levels of biological organization. x
  • 59
    The Structure of Populations
    Our survey of energy and resources moves to the level of populations, in which we define the term population and outline the characteristics of a population from an ecological perspective. x
  • 60
    Population Growth
    This lecture looks at population growth under the ideal conditions of exponential growth and under the more realistic assumptions of logistic growth. x
  • 61
    What Limits Population Growth?
    Does the logistic growth model describe the growth of real populations? The answer is "yes and no." We look at the factors that actually regulate population growth. x
  • 62
    Costs and Benefits of Behavior
    The behavior of an individual changes in a way that maximizes the difference between the costs and benefits that are accrued by that particular behavior. x
  • 63
    Altruism and Mate Selection
    Altruistic interactions are quite common, yet difficult to understand from an evolutionary perspective. An expanded definition of reproductive fitness provides an explanation. x
  • 64
    Ecological Interactions Among Species
    The interaction between predators and their prey is one of the most important in nature. We examine examples of these interactions and the principles that can be derived from them. x
  • 65
    Predators and Competitors
    This lecture looks in more detail at cases in which one species benefits and the other is harmed, and then focuses on competition where both species might be affected adversely by the other's presence. x
  • 66
    Competition and the Ecological Niche
    Continuing the discussion of competition in communities, we look at studies of how a competitive interaction affects species, which leads to the concept of the ecological niche. x
  • 67
    Energy in Ecosystems
    Environments store and release critical resources to the species that live in them. This lecture explores the flow of one such resource—energy—showing how inefficiencies in energy transfer can influence the abundance of a species. x
  • 68
    Nutrients in Ecosystems
    Unlike energy, nutrients are recycled into and out of ecosystems. To illustrate the significance of this fact, we follow the cycles of three critical nutrient elements: carbon, nitrogen, and phosphorus. x
  • 69
    How Predictable Are Ecological Communities?
    Many aspects of the structure and composition of ecological communities have been shown to be unpredictable. As a result, ecologists now focus on patterns of disturbance in communities instead of trying to describe the end-state of ideal communities. x
  • 70
    Biogeography
    Biogeography is the branch of biology that attempts to account for the patterns of distribution of populations, species, and ecological communities on a global scale. We look at examples that illustrate key points. x
  • 71
    Human Population Growth
    For most of history, human population size was limited by the amount of resources available naturally in the environment. But humans have repeatedly redefined ways many resources can be obtained and used, an ability that has led to a dramatic increase in world population. x
  • 72
    The Human Asteroid
    The increasing loss of biodiversity means that species diversity is decreasing at the very moment of our greatest strides in biological understanding. Professor Nowicki closes with reasons for alarm and hope. x

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Stephen Nowicki

About Your Professor

Stephen Nowicki, Ph.D.
Duke University
Dr. Stephen Nowicki is Bass Fellow and Professor of Biology at Duke University. He is also Dean and Vice Provost of Undergraduate Education at Duke, and holds appointments in the Department of Psychological and Brain Sciences and in the Neurobiology Department at Duke University Medical Center. Prior to taking his position at Duke, he was a post-doctoral fellow and assistant professor at The Rockefeller University. Professor...
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Reviews

Biology: The Science of Life is rated 4.5 out of 5 by 97.
Rated 5 out of 5 by from Excellent teacher This was a fantastic overview of biology for someone with minimal background. Information was explained well and review at the end of each lecture. The professor systematically laid out the big picture and overarching themes and then explained how each lecture fit into that scheme. I am so pleased to now understand the mechanisms of DNA and proteins, how muscles work on a molecular level, how life might have originated, and many other former biology mysteries.
Date published: 2018-10-27
Rated 5 out of 5 by from Changed my view of life I've been a Teaching Company customer for a long time, and this is the best course I've ever taken. Even at 36 hours, I've been through it start to finish five times, and I get something new from it every time (I listen on headphones at 1.5x speed while hiking). I really like his presentation, it doesn't sound *at all* like he's reading from a script, and by far my favorite part was understanding about proteins. Formerly I thought of them as static building blocks, like bricks or Lego pieces, but getting to understand that they move in amazingly complicated ways made it "click" for me. Holy cow, ATP is an amazing molecule, and this course prompted an enormous amount of my own research into the science of life. Kinesins! Helicase! All amazing. In this sense, this course changed my very view of life, and - some years later - in an indirect way helped me save my own life. As I was about to undergo (ultimately successful) chemotherapy for colon cancer, all the stuff I learned about from this course and related researched helped me understand the biochemistry of the treatment I was to receive, turning a scary journey into a fascinating one. There were yucky parts of the journey too, of course, but none of it was a mystery. Mysteries are scary. I was in love with this course long before the chemo distraction, and probably should have written a review then, but this sealed the deal. Can't say enough good about this course.
Date published: 2018-10-06
Rated 3 out of 5 by from So far so, so I love the great courses but I only like this course so far. I have finished about 1/4 of this course and it is not especialy interesting or engaging.
Date published: 2018-08-28
Rated 5 out of 5 by from Good explanations. I bought this a few weeks ago and I have watched about 12 lectures. I think the professor explains things in a very understandable way. I bought the Biology book that goes with the course. The text is much easier to comprehend/retain after I have watched the lecture. The professor covers most of the topics in the Biology book chapters recommended as further reading. I will watch the lectures again after I complete the course. Then I will have the "whole picture" and the pieces will fit together.
Date published: 2018-06-16
Rated 5 out of 5 by from One of the best. An absolute gem! This course turned to be one of the highlights for me in TGC out of more than two hundred courses I have heard so far. It is a drill- down, in depth, quite technical course on the very basic mechanisms of biology – with an intense bias towards molecular biology. I felt, prior to hearing the course that I had a reasonable command of Biology – having always been interested in Zoology and reading far and wide on the topic and having studied it quite intensively in high-school. It turns out that this course had a lot to teach me. Though in some aspects I had some understanding, the course went well beyond elementary, or even intermediate descriptions. I particularly found the chapters regarding how the DNA is structured and how this structure enables building proteins, the difference between DNA and the different derivatives of RNA, and genetics in general to be quite technical and challenging but absolutely first rate. Other topics that I particularly enjoyed were the in-depth descriptions of the biochemical energy cycles (both in animals and in plants), cell differentiation in multi-cellular organisms, and the discussion on multi-cellular organism development. The discussions regarding the ecosystem and more macro levels were good, but I did not feel that they were discussed in the same level of depth nor did they induce in the professor, in my opinion, the same level of enthusiasm. Professor Nowicki is phenomenal in my opinion – clear, structured, enthusiastic, patient and in great command of the material. Though he is certainly not boring, he did not make any excessive attempts to make the lectures entertaining. This is strictly a serious academic course. The course is unusually long for TGC – with 72 lectures. There are only a handful of courses in TGC that are of comparable length. I think that it is primarily due to the time allotted to the course that the lectures felt so unrushed, detailed and thorough. Since the course is relatively in depth and technical, I intend to hear it again sometime in the future since there is so much to soak in and it is so FASCINATING. Overall this has been one of the pinnacle learning experiences for me in TGC! The content was breath-takingly interesting, and the Professor taught the material in a way that left almost nothing to be desired. One of the best!
Date published: 2018-01-24
Rated 5 out of 5 by from Gift Gift to my granddaughter who is in high school. Will try to buy more courses.
Date published: 2017-08-11
Rated 4 out of 5 by from Too much history - not enough Biology After 72 lectures, you'd think you'd understand quite a lot about biology. It's 36 hours of biology... You'd think you'd know enough to absolutely pass any freshman course in biology. This isn't the case... What you will come away with is a lot of knowledge about the *history* of biology... Which is disappointing. This is one of the biggest problems science professors make with the Great Courses - they focus way too much time on history, and not enough time on the actual science. I still suggest this course - but only buy it on sale. I think you'll learn a lot of interesting things... But personally, I'm not very satisfied. I think there should be a Biology and our Universe course that has a lot more focus on the science of biology and a lot less on the history of it.
Date published: 2017-07-17
Rated 3 out of 5 by from Haven't started yet as still taking another course... I got the CD version this time. Wish I could copy to laptop, but so far haven't been successful. Wanted to load sessions to laptop to be more portable (able to do with DVDs from other courses). I'm anxious to start this course and hope it doesn't require prior knowledge of biology to start, otherwise, I'll be doing a lot of "Googling".
Date published: 2017-06-16
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